It is hard to believe that 36 years has passed since the first documented case of Acanthamoeba Keratitis.

I attribute our recent success in treating Acanthamoeba Keratitis at the Duke Eye Center to the collaborative work between the Cornea Service and also Dr. John Perfect in the Infectious Disease Department.  Our initial treatment regimen consists of the following:

  1. Discontinue all contact lens wear.  Patients often don’t realize that their other eye is at risk with continued contact lens wear.  Particularly if they are sleeping while wearing their contact lens.
  2. Culturing the case along with their eye often confirms that the contact lens is in fact the source of their infection.
  3. Chlorhexidine gluconate  0.02-0.06% topically 6-12 times per day.   http://www.ncbi.nlm.nih.gov/pmc/articles/PMC180025/pdf/aac00189-0009.pdf
  4. PHMB 0.5% topically 6-12 times per day
  5. Brolene (Dibrompropamidine) 6 times daily]
  6. Neomycin  (Maxitrol) 4-6 times daily
  7. Diflucan (Fluconazole) up to 800 mg daily
  8. Atropine 1% once or twice daily for discomfort
  9. Bromday once daily for pain.
  10. Oral Ibuprofen for pain.