The Duke Eye Center and Drs. Alan N. Carlson, Amina Husain, and Preeya Gupta have been targeting the link between Keratoconus, Floppy Eyelid Syndrome, weight gain, and their discovery of the association with Obstructive Sleep Apnea.  Now there may be evidence that includes a link between Keratoconus and Thyroid Hormones in the Abstract below:

Keratoconus and Thyroid Hormones

Seitz, B; Gatzioufas, Z; Thanos, S

Purpose: To assess the association of thyroid gland dysfunction (TGD) and

keratoconus (KC).

Methods: Examination of serum and tear thyroid hormone levels of 154 KC

patients and controls, estimation of corneal immunohistochemical stainings of

thyroid hormone receptors (THR).

Results: KC patients (13.6%) suffered significantly (p<0.001) more often from

TGD than controls (2.0%). Tear concentration of free thyroid hormone was

significantly higher in KC patients than in controls. The expression of THR in

human corneal epithelium and endothelium was significantly higher in KC

patients than in controls.

Conclusions: Our results demonstrate a strong clinical and

immunohistochemical association between KC disease and TGD. Our data

implicate a crucial role of thyroid hormones in the pathophysiology of

keratoconus, which is likely mediated by hormone receptors, and provide the

possibility for early endocrinologic diagnosis of keratoconus that could help to

prevent its full manifestation by the early treatment of thyroid gland