Researchers enrolled 26 eyes of 13 patients with posterior blepharitis diagnosed by a qualified ophthalmologist to evaluate the effects of oral azithromycin in this patient population.
According to the researchers, all clinical outcomes scoring showed statistically significant improvement after oral azithromycin, except for eyelid swelling. Average subjective symptom grading improved statistically after treatment with oral azithromycin, except for eyelid hyperemia, photophobia and foreign body sensation. Average tear film break-up time values showed statistically significant improvement after the treatment with oral azithromycin. Additionally, the researchers observed no statistically significant improvement on average values of Schirmer I test, corneal fluorescein staining score, and rose Bengal staining score.
This combination of multiple clinical parameters shown in this study supports the clinical efficacy of pulsed oral azithromycin therapy for the management of posterior blepharitis.
SOURCE: Igami TZ, Holzchuh R, Osaki TH, et al. Oral azithromycin for treatment of posterior blepharitis. Cornea. 2011;30(10):1145–1149.
COMMENT: “I am optimistic that this regimen will work in synergy with the new Dry Eye program at Duke Eye Center that will include the latest technology from TearScience that includes the LipiView and LipiFlow units.” Alan N. Carlson, M.D.